Abstract |
An adult patient experienced attacks of severe low back pain and sciatic neuralgia for several years, sometimes associated with myalgias, skin lesions, and high fever. Specific inflammatory laboratory tests were the major abnormalities. P46L mutation in the gene on chromosome 12p13 that encodes tumor necrosis factor receptor superfamily 1A (TNFRSF1A) was found. Management with anti-TNF agent was effective with a complete remission of bouts of pain and fever.
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Authors | Jacques Serratrice, Christine de Roux-Serratrice, Patrick Disdier, Catherine Dodé, Pierre-Jean Weiller |
Journal | Clinical rheumatology
(Clin Rheumatol)
Vol. 26
Issue 9
Pg. 1535-6
(Sep 2007)
ISSN: 0770-3198 [Print] Germany |
PMID | 16941196
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Immunoglobulin G
- Receptors, Tumor Necrosis Factor
- Receptors, Tumor Necrosis Factor, Type I
- Tumor Necrosis Factor-alpha
- Etanercept
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Topics |
- Etanercept
- Fever
(drug therapy, genetics, immunology)
- Humans
- Immunoglobulin G
(therapeutic use)
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Receptors, Tumor Necrosis Factor
(therapeutic use)
- Receptors, Tumor Necrosis Factor, Type I
(drug effects, genetics)
- Sciatica
(complications, drug therapy, genetics)
- Syndrome
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
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