LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression.

Abstract	LRRC4 (leucine rich repeat containing 4), a novel member of LRP (Leucine-rich repeat protein) superfamily, contains a conserved leucine-rich repeat (LRR) cassette and an immunoglobulin-like (IgC2) domain in its extracellular region. In the present study, we demonstrated that the N and C terminal LRR (LRRNT and LRRCT) are requisite for membrane and cytoplasm location of LRRC4 in Cos7 cells. We also suggested that RPTP-zeta (receptor-type protein tyrosine phosphatase) receptor is relevant to the invasion ability of gliomas cells, and its expression is inhibited by the reexpression of LRRC4. Our observations indicated that LRRC4 may be a negative regulator of the RPTP-zeta receptor, and contribute to suppressing the invasion ability of gliomas cells.
Authors	Minghua Wu, Kai Gan, Chen Huang, Yunlian Tang, Qiong Chen, Ke Tang, Xiaoling Li, Shourong Shen, Guiyuan Li
Journal	Journal of neuro-oncology (J Neurooncol) Vol. 80 Issue 2 Pg. 133-42 (Nov 2006) ISSN: 0167-594X [Print] United States
PMID	16941076 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	LRRC4 protein, human Nerve Tissue Proteins Recombinant Fusion Proteins Glyceraldehyde-3-Phosphate Dehydrogenases PTPRZ1 protein, human Protein Tyrosine Phosphatases Receptor-Like Protein Tyrosine Phosphatases, Class 5
Topics	Amino Acid Sequence Cell Communication (physiology) Cells, Cultured Central Nervous System Neoplasms (genetics, pathology) Diffusion Chambers, Culture Gap Junctions (physiology) Gene Deletion Glioblastoma (genetics, pathology) Glyceraldehyde-3-Phosphate Dehydrogenases (physiology) Humans Microscopy, Fluorescence Molecular Sequence Data Neoplasm Invasiveness (genetics, pathology) Nerve Tissue Proteins (physiology) Plasmids (genetics) Protein Tyrosine Phosphatases (antagonists & inhibitors, biosynthesis) Receptor-Like Protein Tyrosine Phosphatases, Class 5 Recombinant Fusion Proteins (genetics) Reverse Transcriptase Polymerase Chain Reaction Scrapie (pathology) Transfection

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