Abstract | AIMS: The objective of the Coronary Calcification (CC) study was to determine in patients with chronic symptomatic coronary artery disease, if, in addition to standard therapy, nifedipine GITS, relative to placebo, would arrest or slow down the progression of calcium or the development of new atherosclerotic lesions in the coronary arteries. METHODS AND RESULTS: The CC study was part of the ACTION trial. Multi-slice computerized tomography was used to measure and track the progression of CC. Five hundred and eighteen patients were included in this study. The changes in calcium score from baseline every 24 months, over a period of between 4.5 and 6 years, were similar in the nifedipine and placebo treatment groups (p = 0.8). Compared to placebo, more patients in the nifedipine group (71 vs. 60%) were free of new calcified atherosclerotic lesions during follow-up(p = 0.095). CONCLUSION:
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Authors | Michael Motro, Bridget-Anne Kirwan, Sophie de Brouwer, Philip A Poole-Wilson, Joseph Shemesh, ACTION CC side-arm study |
Journal | Cardiology
(Cardiology)
Vol. 107
Issue 3
Pg. 165-71
( 2007)
ISSN: 1421-9751 [Electronic] Switzerland |
PMID | 16940720
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2007 S. Karger AG, Basel. |
Chemical References |
- Calcium Channel Blockers
- Nifedipine
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Topics |
- Aged
- Angina Pectoris
(drug therapy)
- Atherosclerosis
(drug therapy, pathology)
- Calcinosis
(drug therapy, pathology)
- Calcium Channel Blockers
(therapeutic use)
- Coronary Vessels
(pathology)
- Female
- Humans
- Male
- Middle Aged
- Nifedipine
(therapeutic use)
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