Abstract | INTRODUCTION: OBJECTIVES: The objectives of the study were: 1) to determine the rate of severe oligospermia (< or = 1 million sperm/ml) using T gel+DMPA; and 2) to determine whether the addition of acyline to T gel+DMPA during the first 12 wk of the regimen would accelerate and improve suppression of spermatogenesis. METHODS: Forty-four healthy men, ages 18-55 yr, were randomized to T gel (100 mg daily)+ DMPA (300 mg/3 months) or acyline (300 microg/kg.2 wk x 12 wk)+T gel+DMPA. Thirty-eight men completed the 24-wk treatment protocol. RESULTS: All men had dramatic suppression of spermatogenesis; 90% of the subjects became severely oligospermic, a rate comparable to implantable and injectable T+progestin combinations. The addition of acyline did not significantly accelerate spermatogenic suppression or improve rates of severe oligospermia. There were no serious adverse events, and there were minimal changes in weight, serum lipids, and prostate-specific antigen. CONCLUSIONS:
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Authors | Stephanie T Page, John K Amory, Bradley D Anawalt, Michael S Irwig, Andrew T Brockenbrough, Alvin M Matsumoto, William J Bremner |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 91
Issue 11
Pg. 4374-80
(Nov 2006)
ISSN: 0021-972X [Print] United States |
PMID | 16940442
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Contraceptive Agents, Male
- Drug Combinations
- Gels
- Gonadotropins
- Insulin
- Leydig insulin-like protein
- Lipids
- Proteins
- Sex Hormone-Binding Globulin
- Gonadotropin-Releasing Hormone
- Testosterone
- Medroxyprogesterone Acetate
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Topics |
- Administration, Topical
- Adolescent
- Adult
- Body Weight
(drug effects)
- Contraceptive Agents, Male
(administration & dosage, adverse effects, pharmacology)
- Drug Administration Routes
- Drug Combinations
- Gels
- Gonadotropin-Releasing Hormone
(antagonists & inhibitors)
- Gonadotropins
(blood)
- Humans
- Injections, Subcutaneous
- Insulin
(blood)
- Lipids
(blood)
- Male
- Medroxyprogesterone Acetate
(administration & dosage, adverse effects, pharmacology)
- Middle Aged
- Proteins
- Sex Hormone-Binding Globulin
(analysis)
- Sperm Count
- Spermatogenesis
(drug effects)
- Testosterone
(administration & dosage, adverse effects, blood, pharmacology)
- Treatment Outcome
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