Abstract | BACKGROUND: METHODS AND RESULTS: Twenty-four critical limb ischemia patients (16 men and 8 women, mean age 76+/-9.7 years) were included in the study and treated with intravenous iloprost (titrated from 0.5 up to 1.5 ng/kg/min) for 16 h a day for seven consecutive days. Blood samples were drawn before infusion on days 1, 4 and 8 of treatment, under the same conditions. Clinical assessment was performed by clinical evaluation, ankle/brachial pressure index and treadmill exercise test. During treatment with iloprost patients clinically improved and plasma levels of ADMA significantly decreased (p<0.001). We also observed a significant increase of serotonin (p<0.01) in platelets and a significant decrease of serotonin (p<0.001) in plasma. Similar variations of ADMA and serotonin were found in two subgroups of patients, diabetics and non-diabetics. CONCLUSIONS:
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Authors | Patrizia Blardi, Arianna de Lalla, Daniela Pieragalli, Vincenzo De Franco, Simone Meini, Linda Ceccatelli, Alberto Auteri |
Journal | Prostaglandins & other lipid mediators
(Prostaglandins Other Lipid Mediat)
Vol. 80
Issue 3-4
Pg. 175-82
(Sep 2006)
ISSN: 1098-8823 [Print] United States |
PMID | 16939882
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Platelet Aggregation Inhibitors
- Serotonin
- N,N-dimethylarginine
- Arginine
- Iloprost
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Topics |
- Aged
- Aged, 80 and over
- Arginine
(analogs & derivatives, blood)
- Arterial Occlusive Diseases
(blood, complications, drug therapy)
- Blood Platelets
(chemistry, drug effects)
- Blood Pressure
(drug effects)
- Diabetes Mellitus, Type 2
(blood, complications)
- Drug Administration Schedule
- Exercise Test
- Female
- Humans
- Iloprost
(administration & dosage, pharmacology, therapeutic use)
- Infusions, Intravenous
- Male
- Peripheral Vascular Diseases
(blood, complications, drug therapy)
- Platelet Aggregation Inhibitors
(administration & dosage, pharmacology, therapeutic use)
- Serotonin
(blood)
- Treatment Outcome
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