Abstract |
This report describes the case of a 4-year-old boy diagnosed with Smith-Magenis syndrome in whom treatment with a beta(1)-adrenergic antagonist in the morning (to suppress the diurnal melatonin secretion) and melatonin in the evening (to generate a nocturnal peak of melatonin) improved his sleep quality, evaluated by polysomnographic studies.
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Authors | Rosario Carpizo, Angeles Martínez, Dolores Mediavilla, Mónica González, Araceli Abad, Emilio J Sánchez-Barceló |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 149
Issue 3
Pg. 409-11
(Sep 2006)
ISSN: 0022-3476 [Print] United States |
PMID | 16939758
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Adrenergic beta-Antagonists
- Antioxidants
- Acebutolol
- Melatonin
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Topics |
- Acebutolol
(administration & dosage)
- Adrenergic beta-Antagonists
(administration & dosage)
- Antioxidants
(administration & dosage)
- Child, Preschool
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- Chronotherapy
- Humans
- Male
- Melatonin
(administration & dosage)
- Sleep Disorders, Circadian Rhythm
(drug therapy, genetics)
- Syndrome
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