Abstract | OBJECTIVE: STUDY DESIGN: Between September 2000 and March 2005, we randomly assigned 178 KD patients from 12 hospitals to either an intravenous immunoglobulin ( IVIG) group (n = 88; 1 g/kg for 2 consecutive days) or an IVIG plus corticosteroid (IVIG+PSL) group (n = 90). The primary endpoint was coronary artery abnormality (CAA) before a 1-month echocardiographic assessment. Secondary endpoints included duration of fever, time to normalization of serum C-reactive protein (CRP), and initial treatment failure requiring additional therapy. Analyses were based on intention to treat. RESULTS: Baseline characteristics of groups were similar. Fewer IVIG+PSL patients than IVIG patients had a CAA before 1 month (2.2% vs 11.4%; P = .017). The duration of fever was shorter (P < .001) and CRP decreased more rapidly in the IVIG+PSL group than in the IVIG group (P = .001). Moreover, initial treatment failure was less frequent (5.6% vs 18.2%; P = .010) in the IVIG+PSL group. All patients assigned to the IVIG+PSL group completed treatment without major side effects. CONCLUSIONS:
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Authors | Yoshinari Inoue, Yasunori Okada, Makoto Shinohara, Tohru Kobayashi, Tomio Kobayashi, Takeshi Tomomasa, Kazuo Takeuchi, Akihiro Morikawa |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 149
Issue 3
Pg. 336-341
(Sep 2006)
ISSN: 0022-3476 [Print] United States |
PMID | 16939743
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Glucocorticoids
- Immunoglobulins, Intravenous
- Immunologic Factors
- Prednisolone
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Topics |
- Child
- Child, Preschool
- Coronary Aneurysm
(chemically induced, diagnostic imaging, prevention & control)
- Drug Therapy, Combination
- Female
- Glucocorticoids
(administration & dosage, adverse effects)
- Humans
- Immunoglobulins, Intravenous
(administration & dosage)
- Immunologic Factors
(administration & dosage)
- Infant
- Male
- Mucocutaneous Lymph Node Syndrome
(diagnostic imaging, drug therapy)
- Prednisolone
(administration & dosage, adverse effects)
- Prospective Studies
- Treatment Outcome
- Ultrasonography
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