Feasibility and response to 1-(4-amino-2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride chemotherapy with pre-treated procarbazine for elderly patients with newly diagnosed glioblastoma.

Abstract

PURPOSE:

To evaluate the feasibility of 1-(4-amino- 2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) of pre-treated procarbazine for elderly patients with newly diagnosed glioblastomas.

PATIENTS AND METHODS:

From January 2004 to March 2005, 7 patients with glioblastoma were enrolled. After maximal surgical resection, patients were treated with two to four cycles of procarbazine (100 mg/m(2) for day 1 to 5), ACNU (80 mg/m(2)/day(1) for day 5), cepharantine (70 mg for day 5 and 12) and vincristine (1.4 mg/m(2) for day 5 and 12).

RESULTS:

Significant toxicities of this regimen, including infectious toxicities, are described. Among the 7 patients enrolled, there were 6 patients were died, and one was still alive with disease at 13 months. The 6-month progression-free survival and 1-year overall survival are 29% (95% CI, 16% to 73%) and 29% (95% CI, 16% to 73%), respectively.

CONCLUSION:

The chemotherapy regimen is active but too toxic for elderly patients with newly diagnosed glioblastoma.

• Authors: Mizuhiko Terasaki, Toshi Abe, Naohisa Miyagi, Etsuyo Ogo, Minoru Shigemori
• Journal: Journal of neuro-oncology (J Neurooncol) Vol. 81 Issue 3 Pg. 265-9 (Feb 2007) ISSN: 0167-594X [Print] United States
• PMID: 16937011 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Alkaloids
• Benzylisoquinolines
• Nimustine
• Procarbazine
• Vincristine
• cepharanthine

Topics

• Aged
• Alkaloids (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Benzylisoquinolines
• Brain Neoplasms (drug therapy, mortality)
• Disease-Free Survival
• Feasibility Studies
• Female
• Glioblastoma (drug therapy, mortality)
• Humans
• Male
• Middle Aged
• Neutropenia (chemically induced)
• Nimustine (therapeutic use)
• Procarbazine (therapeutic use)
• Survival Analysis
• Treatment Outcome
• Vincristine (therapeutic use)