Abstract | BACKGROUND: METHODS AND RESULTS: Eight beagle dogs were created with a myocardial infarction under anesthesia, and then VT/VF induction by continuous stimulation and cardiopulmonary resuscitation ( CPR) were repeated. NIF (0.3 mg/kg) was administered under acidotic conditions (pH 7.26). The QTc interval measured by Y-lead ECG showed no significant prolongation before and after NIF. The activation recovery interval (ARI) measured by 64-lead LV surface mapping showed minimum ARI prolongation (40%) by NIF without maximum ARI prolongation, and as a result the ARI dispersion decreased by 67%. The repolarization time (RPT) with the plunge electrode showed 13-19% prolongation in the subendocardium and subepicardium with CPR, but NIF prolonged the RPT in the middle layer alone (17%), and as a result Plunge-TDR decreased by 82% (n=8, p<0.05). CONCLUSIONS: Administration of NIF during CPR decreased the TDR by RPT prolongation selectively in the middle layer. Because the subendocardial and subepicardial RPTs after CPR were already prolonged before NIF administration, it may have been the reason why the QT-prolonging effect of NIF was not reflected in the body surface ECG.
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Authors | Koichiro Yoshioka, Mari Amino, Kazutane Usui, Atsuhiko Sugimoto, Atsushi Matsuzaki, Kumiko Kohzuma, Shigetaka Kanda, Yoshiaki Deguchi, Yuji Ikari, Itsuo Kodama, Teruhisa Tanabe |
Journal | Circulation journal : official journal of the Japanese Circulation Society
(Circ J)
Vol. 70
Issue 9
Pg. 1200-7
(Sep 2006)
ISSN: 1346-9843 [Print] Japan |
PMID | 16936437
(Publication Type: Journal Article)
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Chemical References |
- Anti-Arrhythmia Agents
- Pyrimidinones
- nifekalant
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Topics |
- Animals
- Anti-Arrhythmia Agents
(administration & dosage)
- Cardiopulmonary Resuscitation
(methods)
- Disease Models, Animal
- Dogs
- Heart Arrest
(therapy)
- Heart Conduction System
(drug effects)
- Humans
- Pyrimidinones
(administration & dosage)
- Tachycardia, Ventricular
(therapy)
- Ventricular Fibrillation
(therapy)
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