Squalamine lactate for exudative age-related macular degeneration.

Abstract

Squalamine lactate inhibits angiogenesis by a long-lived, intracellular mechanism of action. The drug is taken up into activated endothelial cells through caveolae, small invaginations in the cellular membrane. Subsequently, the drug binds to and "chaperones" calmodulin to an intracellular membrane compartment and blocks angiogenesis at several levels. A series of basic investigations, preclinical studies, and human clinical trials have begun to establish the proof of concept, efficacy, and safety parameters for use of squalamine lactate as a therapeutic agent for exudative age-related macular degeneration and several types of malignancies.

• Authors: Brian Connolly, Avinash Desai, Charles A Garcia, Edgar Thomas, Michael J Gast
• Journal: Ophthalmology clinics of North America (Ophthalmol Clin North Am) Vol. 19 Issue 3 Pg. 381-91, vi (Sep 2006) ISSN: 0896-1549 [Print] United States
• PMID: 16935213 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Cholestanols
• Lactates
• squalamine lactate

Topics

• Animals
• Cholestanols (therapeutic use)
• Exudates and Transudates
• Humans
• Lactates (therapeutic use)
• Macular Degeneration (drug therapy)
• Treatment Outcome