Abstract |
Delta agonists such as SNC80 ((+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide) produce some cocaine-like behavioral effects and warrant evaluation as candidate "agonist" medications for cocaine abuse. The present study examined acute and chronic effects of the systemically active delta agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys. Acute SNC80 (0.32-3.2 mg/kg, i.m.) pretreatment dose-dependently decreased cocaine self-administration (0.0032 mg/kg/injection), but doses of SNC80 that decreased cocaine self-administration also decreased food-maintained responding. In chronic studies, SNC80 (0.32-3.2 mg/kg/h, i.v.) was delivered for 7 days, and food or cocaine (0.01 mg/kg/injection) was available during 4 daily components of food availability and 4 daily components of drug availability. Chronic SNC80 (1.8 mg/kg/h) tended to decrease cocaine self-administration but produced greater reductions in food-maintained responding. A higher dose of 3.2 mg/kg/h SNC80 eliminated both cocaine- and food-maintained responding and produced profound sedation in one monkey and was not tested in other monkeys. These findings indicate that SNC80 produced dose-dependent and non-selective reductions in cocaine self-administration. These results suggest that SNC80 is unlikely to be useful as a treatment for cocaine dependence.
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Authors | Gail Pereira Do Carmo, Nancy K Mello, Kenner C Rice, John E Folk, S Stevens Negus |
Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 547
Issue 1-3
Pg. 92-100
(Oct 10 2006)
ISSN: 0014-2999 [Print] Netherlands |
PMID | 16934797
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural)
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Chemical References |
- Benzamides
- Piperazines
- Receptors, Opioid, delta
- 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide
- Cocaine
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Topics |
- Analysis of Variance
- Animals
- Behavior, Animal
(drug effects)
- Benzamides
(pharmacology)
- Cocaine
(administration & dosage)
- Cocaine-Related Disorders
(physiopathology, prevention & control, psychology)
- Conditioning, Operant
(drug effects)
- Dose-Response Relationship, Drug
- Female
- Food
- Macaca mulatta
- Male
- Piperazines
(pharmacology)
- Receptors, Opioid, delta
(agonists)
- Reinforcement Schedule
- Self Administration
- Time Factors
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