Successful treatment with rasburicase of a tophaceous gout in a patient allergic to allopurinol.

• Abstract: BACKGROUND: A 56-year-old white woman was referred to our institution with a 16-month history of severe, gouty, recurrent, acute polyarthritis involving the finger joints. She also had numerous small subcutaneous tophi in her hands. The patient was intolerant to allopurinol and had mild renal insufficiency attributed to uric-acid nephrolithiasis and interstitial nephropathy. INVESTIGATIONS: Physical examination, laboratory testing, X-rays of the hands, feet and pelvis, CT of the pelvis, microscopic analysis of an aspirate from a finger tophus. DIAGNOSIS: Tophaceous gout associated with urate nephropathy in a patient intolerant to allopurinol. MANAGEMENT: Acute polyarthritis was successfully managed by intravenous bolus methylprednisolone combined with codeine, diclofenac and low-dose colchicine. Rasburicase infusions combined with fenofibrate and sodium bicarbonate achieved to maintain serum acid uric below 360 micromol/l.
• Authors: Pascal Richette, Thomas Bardin (Affiliation: Department of Rheumatology, Centre Viggo Petersen, Lariboisiere Hospital, University Paris VII, France. pascal.richette at lrb.ap-hop-paris.fr)
• Journal: Nature clinical practice. Rheumatology (Nat Clin Pract Rheumatol) Vol. 2 Issue 6 Pg. 338-42; quiz 343 (Jun 2006) ISSN: 1745-8382 [Print] United States
• PMID: 16932713 (Publication Type: Case Reports, Journal Article)

Chemical References

• Gout Suppressants
• Recombinant Proteins
• Allopurinol
• Urate Oxidase
• rasburicase

Topics

• Allopurinol (adverse effects)
• Arthritis, Gouty (diagnosis, drug therapy)
• Diagnosis, Differential
• Female
• Finger Joint
• Gout Suppressants (adverse effects)
• Humans
• Hypersensitivity (etiology)
• Middle Aged
• Recombinant Proteins (therapeutic use)
• Severity of Illness Index
• Urate Oxidase (therapeutic use)