Abstract | BACKGROUND: DESIGN: Retrospective clinicopathologic review of 45 cases of active noninfectious aortitis among 513 consecutive ascending aortic resections (1985 to 1999). METHODS: Clinical data were collected from medical records. Histopathologic features were recorded during review of slides stained with hematoxylin- eosin and Verhoeff-van Gieson. Cases were categorized by predefined clinical criteria. Clinicopathologic features were compared among groups, with emphasis on unsuspected aortitis without systemic arteritis. RESULTS: CONCLUSIONS:
Aortitis primarily affected women. Patients with isolated aortitis and giant cell arteritis were generally older than 50 years and, by definition, those with Takayasu arteritis were younger. In patients with isolated aortitis, outcomes were generally good, despite the absence of anti-inflammatory therapy. Accordingly, a conservative approach may be warranted for managing this subset of patients with aortitis.
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Authors | Dylan V Miller, Phillip A Isotalo, Cornelia M Weyand, William D Edwards, Marie-Christine Aubry, Henry D Tazelaar |
Journal | The American journal of surgical pathology
(Am J Surg Pathol)
Vol. 30
Issue 9
Pg. 1150-8
(Sep 2006)
ISSN: 0147-5185 [Print] United States |
PMID | 16931960
(Publication Type: Journal Article)
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Topics |
- Aged
- Aged, 80 and over
- Aorta
(pathology)
- Aortic Aneurysm
(etiology)
- Aortitis
(complications, pathology)
- Female
- Giant Cell Arteritis
(pathology)
- Humans
- Male
- Middle Aged
- Retrospective Studies
- Rheumatic Diseases
(pathology)
- Takayasu Arteritis
(pathology)
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