Brinzolamide 1% versus apraclonidine 0.5% to prevent intraocular pressure elevation after neodymium:YAG laser posterior capsulotomy.

Abstract

PURPOSE:

To compare the efficacy of brinzolamide 1% with that of apraclonidine 0.5% in preventing intraocular pressure (IOP) rise after neodymium:YAG (Nd:YAG) laser posterior capsulotomy.

SETTING:

Department of Ophthalmology, Akdeniz University, Antalya, Turkey.

METHODS:

One hundred fifteen patients who had Nd:YAG laser posterior capsulotomy for posterior capsule opacification were prospectively randomized to receive brinzolamide 1% (57 patients) or apraclonidine 0.5% (58 patients) approximately 1 hour before laser surgery. A masked observer measured IOP by Goldmann applanation tonometry before treatment and after treatment at 1, 2, and 3 hours and 7 days.

RESULTS:

The mean IOP changes from baseline were not statistically different between the study groups at 1, 2, and 3 hours and 7 days (P =.109, P = .764, P =.275, and P =.879, respectively). The incidence of IOP elevation of 5 mm Hg or higher was 12.2% (7 of 57 eyes) in the brinzolamide group and 10.3% (6 of 58 eyes) in the apraclonidine group (P = .743); IOP elevations of 10 mm Hg and greater occurred in 3.5% (2 of 57 eyes) and 1.7% (1 of 58 eyes) (P = .618), respectively. There were no IOP elevations greater than 20 mm Hg in either group.

CONCLUSION:

Brinzolamide 1% and apraclonidine 0.5% given prophylactically before Nd:YAG laser capsulotomy were effective in preventing IOP spikes after treatment.

• Authors: Mustafa Unal, Iclal Yücel, Yusuf Akar
• Journal: Journal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 32 Issue 9 Pg. 1499-502 (Sep 2006) ISSN: 0886-3350 [Print] United States
• PMID: 16931262 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Adrenergic alpha-Agonists
• Carbonic Anhydrase Inhibitors
• Ophthalmic Solutions
• Sulfonamides
• Thiazines
• apraclonidine
• brinzolamide
• Clonidine

Topics

• Adrenergic alpha-Agonists (therapeutic use)
• Adult
• Aged
• Aged, 80 and over
• Carbonic Anhydrase Inhibitors (therapeutic use)
• Clonidine (analogs & derivatives, therapeutic use)
• Double-Blind Method
• Female
• Humans
• Intraocular Pressure (drug effects)
• Laser Therapy (adverse effects)
• Lens Capsule, Crystalline (pathology, surgery)
• Male
• Middle Aged
• Ocular Hypertension (etiology, prevention & control)
• Ophthalmic Solutions (therapeutic use)
• Postoperative Complications (prevention & control)
• Premedication
• Prospective Studies
• Sulfonamides (therapeutic use)
• Thiazines (therapeutic use)
• Tonometry, Ocular