An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva.

Abstract	The present study examined histological difference between ossifying fibromas (OF, n=5) and peripheral cemento-ossifying fibromas (PCOF, n=7). Bone morphogenetic proteins (BMP)-2 and -4, osteopontin (OPN), osteocalcin (OCN) and proliferating cell nuclear antigen (PCNA) were used for the immunohistochemical examinations. Oxytalan fibers present at the periodontal tissue were stained to determine the tumor cell origin. Many OFs showed high immunohistochemical reactions for BMP-2, -4 and OPN compared to those of PCOFs. PCNA index (IP) of OFs was significantly higher than that of PCOFs. All the PCOFs showed a high expression of oxytalan fibers. Only two OFs exhibited a small number of oxytalan fibers. These results suggest that PCOF has only little ability to form hard tissue and seems to be a reactive lesion. The expression of oxytalan fibers reveals that OF does not only originate from periodontal tissue.
Authors	Akiko Ono, Goichi Tsukamoto, Hitoshi Nagatsuka, Yasuto Yoshihama, Rosario Santos Rivera, Miki Katsurano, Mayumi Yao, Akira Sasaki
Journal	Oral oncology (Oral Oncol) Vol. 43 Issue 4 Pg. 339-44 (Apr 2007) ISSN: 1368-8375 [Print] England
PMID	16931115 (Publication Type: Comparative Study, Journal Article)
Chemical References	BMP2 protein, human BMP4 protein, human Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins Proliferating Cell Nuclear Antigen Transforming Growth Factor beta Osteocalcin Osteopontin
Topics	Adolescent Adult Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins (metabolism) Calcinosis (metabolism, pathology) Child Female Fibroma, Ossifying (metabolism, pathology) Gingival Hyperplasia (metabolism, pathology) Gingival Neoplasms (metabolism, pathology) Humans Immunohistochemistry Jaw Neoplasms (metabolism, pathology) Male Middle Aged Osteocalcin (metabolism) Osteopontin (metabolism) Proliferating Cell Nuclear Antigen (metabolism) Transforming Growth Factor beta (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!