Lymphomatoid papulosis with antigen deletion and clonal rearrangement in a 4-year-old boy.

Abstract

Lymphomatoid papulosis (LyP) is rarely seen in children. We report a case of LyP in a 4-year-old boy in whom immunopathologic studies demonstrated T cell antigen deletions. In contrast to all but two previous reports, a T suppressor (CD-8) phenotype was predominant. Southern blot analysis of DNA isolated from a typical skin lesion indicated a clonal rearrangement of the T cell receptor beta gene. Because of a 10% frequency of malignant lymphomas in patients with LyP, long-term observation is crucial, especially in children. We recommend routine clonal rearrangement studies for aid in diagnosis and follow-up, and as possible prognostic indicators in children with this condition.

• Authors: J Hellman, R G Phelps, J Baral, T M Fasy, C M Ahern, J A Strauchen
• Journal: Pediatric dermatology (Pediatr Dermatol) Vol. 7 Issue 1 Pg. 42-7 (Mar 1990) ISSN: 0736-8046 [Print] United States
• PMID: 1692995 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, CD
• Epitopes
• Receptors, Antigen, T-Cell

Topics

• Antigens, CD (immunology)
• Blotting, Southern
• Child
• Child, Preschool
• Clone Cells
• Epitopes (immunology)
• Female
• Gene Rearrangement, T-Lymphocyte
• Humans
• Infant
• Male
• Receptors, Antigen, T-Cell (genetics)
• Skin Diseases (genetics, immunology, pathology)
• T-Lymphocytes (immunology)