Intravenous pantoprazole as initial treatment in patients with gastroesophageal reflux disease and a history of erosive esophagitis: a randomized clinical trial.

Abstract

We sought to evaluate safety and efficacy of IV pantoprazole when used as initial therapy in patients with gastroesophageal reflux disease (GERD) and a history of erosive esophagitis (EE) in a double-blind, placebo-controlled, randomized, parallel-group study. Patients were randomized to 7 days of once-daily IV or oral pantoprazole (40 mg) or placebo. Efficacy variables included maximal acid output, basal acid output, and changes from baseline in frequency/severity of GERD symptoms, and frequency of antacid usage. Seventy-eight patients were randomized (n=26/27/25 [IV/oral/placebo]). Mean maximal acid output was 8.4, 6.3, and 20.9 mEq/h for IV or oral pantoprazole, and placebo, respectively. For pantoprazole versus placebo, maximal and basal acid output were significantly lower (P<.001) and there was a numerical trend toward improved GERD and antacid usage. Both treatments were well tolerated. In conclusion, IV/oral pantoprazole were similarly effective in suppressing basal and pentagastrin-stimulated gastric acid secretion in GERD patients with a history of EE.

• Authors: Vijaya Pratha, Daniel L Hogan, Richard B Lynn, Brian Field, David C Metz
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 51 Issue 9 Pg. 1595-601 (Sep 2006) ISSN: 0163-2116 [Print] United States
• PMID: 16927137 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Anti-Ulcer Agents
• Benzimidazoles
• Drug Combinations
• Sulfoxides
• Silicic Acid
• Aluminum Hydroxide
• Gelusil
• Pantoprazole
• Omeprazole
• Magnesium Hydroxide

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Administration, Oral
• Adult
• Aluminum Hydroxide (therapeutic use)
• Analysis of Variance
• Anti-Ulcer Agents (administration & dosage, adverse effects)
• Benzimidazoles (administration & dosage, adverse effects)
• Body Weights and Measures
• Double-Blind Method
• Drug Combinations
• Esophagitis, Peptic (drug therapy, etiology)
• Female
• Gastric Acid (physiology)
• Gastric Acidity Determination
• Gastroesophageal Reflux (complications, drug therapy)
• Humans
• Infusions, Intravenous
• Magnesium Hydroxide (therapeutic use)
• Male
• Middle Aged
• Omeprazole (administration & dosage, adverse effects, analogs & derivatives)
• Pantoprazole
• Placebo Effect
• Severity of Illness Index
• Silicic Acid (therapeutic use)
• Sulfoxides (administration & dosage, adverse effects)
• Treatment Outcome