Abstract | BACKGROUND: METHODS: Patients undergoing laparoscopic Roux-en-Y gastric bypass surgery (RYGB) for morbid obesity had lipid analyses performed preoperatively and 1 and 2 years postoperatively. The number of lipid-modifying medications taken was documented by an electronic medical record review. RESULTS: A total of 168 patients were enrolled. Of these, 96 patients had preoperative and 1-year postoperative data and 18 had preoperative and 2-year postoperative data. In the 1-year cohort, total cholesterol (TC) decreased by 12.5%, low-density lipoprotein cholesterol ( LDL) decreased by 19.4%, high-density lipoprotein cholesterol (HDL) increased by 23.2%, triglycerides (TG) decreased by 41.2%, and the percentage of dyslipidemic patients decreased from 82.3% to 28.1% (P < .001 for all). In the 2-year cohort, TC decreased by 7.2% (P = .036), LDL decreased by 21.7% (P < .001), HDL increased by 40.3% (P < .001), TG decreased by 27.3% (P = .015), and the percentage of dyslipidemic patients decreased from 94.4% to 27.8% (P < .001). In the 1-year cohort, 26.0% of patients were taking lipid-modifying medications preoperatively, compared with 14.6% postoperatively (P = .049). CONCLUSIONS: Laparoscopic RYGB improved all lipid parameters studied and decreased the percentage of dyslipidemic patients. Furthermore, fewer patients were taking lipid-modifying medications postoperatively, suggesting a substantial medication cost savings over time.
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Authors | Jonathan A Zlabek, Melissa S Grimm, Christopher J Larson, Michelle A Mathiason, Pamela J Lambert, Shanu N Kothari |
Journal | Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
(Surg Obes Relat Dis)
2005 Nov-Dec
Vol. 1
Issue 6
Pg. 537-42
ISSN: 1550-7289 [Print] United States |
PMID | 16925287
(Publication Type: Journal Article)
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Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Cholesterol
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Topics |
- Adult
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Comorbidity
- Dyslipidemias
(blood, epidemiology)
- Female
- Gastric Bypass
(methods)
- Humans
- Laparoscopy
- Male
- Middle Aged
- Obesity, Morbid
(epidemiology, surgery)
- Postoperative Period
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