A rare cause of polyhydramnios: Neu-Laxova syndrome.

Abstract

Neu-Laxova syndrome is a rare group of congenital malformations including intrauterine growth retardation (IUGR), microcephaly, central nervous system alterations, facial abnormalities, ichthyosis, limb abnormalities, generalized edema, polyhydramnios, and perinatal death. Thirty cases have been identified since the publication of the first two cases and only five of them had a prenatal diagnosis. The earliest diagnosis in a published case was at week 32 of gestation. This study illustrates that the detection of the syndrome during the second trimester of gestation is possible, with emphasis on the detection of the early appearance of polyhydramnios and the association of the syndrome with the Arabic ethnic group.

• Authors: Alicia Martín, Idoya Eguiluz, Miguel A Barber, Norberto Medina, Walter Plasencia, Alfredo García-Alix, José A García-Hernández
• Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (J Matern Fetal Neonatal Med) Vol. 19 Issue 7 Pg. 439-42 (Jul 2006) ISSN: 1476-7058 [Print] England
• PMID: 16923700 (Publication Type: Case Reports, Journal Article)

Topics

• Abnormalities, Multiple (diagnostic imaging)
• Chromosome Disorders
• Craniofacial Abnormalities (diagnostic imaging)
• Diagnosis, Differential
• Female
• Fetal Death
• Fetal Growth Retardation (diagnostic imaging)
• Humans
• Limb Deformities, Congenital (diagnostic imaging)
• Nervous System Malformations (diagnostic imaging)
• Polyhydramnios (diagnostic imaging, etiology)
• Pregnancy
• Prenatal Diagnosis
• Syndrome
• Ultrasonography, Prenatal