Interactions of poly(tert-butyl acrylate)-poly(styrene) diblock copolymers with lipids at the air-water interface.

Abstract

Diblock copolymers with hydrophilic poly(tert-butyl acrylate) (PtBA) and hydrophobic poly(styrene) (PS) blocks were synthesized with a view to use them as a surfactant in tear film for increasing the ocular comfort in dry eye syndrome. Interactions of six PtBA-PS copolymers with four important lipids found in the tear film, namely cholesterol, cholesteryl palmitate, dipalmitoyl phosphatidylcholine, and phosphatidylinositol, were studied at the air-water interface using a Langmuir trough. Thermodynamics of mixing of the copolymers and the lipids in the mixed monolayers was determined by calculating excess free energy of mixing. The diblock copolymers showed repulsive interactions with cholesteol and cholesteryl palmitate, near neutral interactions with dipalmitoyl phosphatidylcholine, and attractive interactions with phosphatidylinositol. The lipids interacted with the PS component of the copolymer. The results indicate that a copolymer with a small hydrophilic group and a big hydrophobic group can be a likely candidate for forming stable interactions with the lipids present in the tear film and hence increase the ocular comfort.

• Authors: Poonam Mudgil, Gary R Dennis, Thomas J Millar
• Journal: Langmuir : the ACS journal of surfaces and colloids (Langmuir) Vol. 22 Issue 18 Pg. 7672-7 (Aug 29 2006) ISSN: 0743-7463 [Print] United States
• PMID: 16922549 (Publication Type: Journal Article)

Chemical References

• Acrylates
• Lipids
• Polystyrenes
• poly(styrene-b-tert-butylacrylate)
• Water

Topics

• Acrylates (chemistry)
• Air
• Lipids (chemistry)
• Molecular Weight
• Polystyrenes (chemistry)
• Temperature
• Thermodynamics
• Water (chemistry)