Transvalencin Z, a new antimicrobial compound with salicylic acid residue from Nocardia transvalensis IFM 10065.

Abstract

Transvalencin Z was isolated from a culture broth of Nocardia transvalensis IFM 10065, a clinical isolate from a Japanese patient with actinomycotic mycetoma. The transvalencin Z structure was determined using NMR and mass spectrometric analyses. The structure is similar to a partial structure of siderophores such as mycobactins and nocobactins, but the compound has no cytotoxic activity. Transvalencin Z shows a strong antimicrobial activity against Gram-positive bacteria, but shows no activity against Gram-negative bacteria, fungi and tumor cells.

• Authors: Akira Mukai, Toshio Fukai, Yuko Matsumoto, Jun Ishikawa, Yasutaka Hoshino, Katsukiyo Yazawa, Ken-ichi Harada, Yuzuru Mikami
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 59 Issue 6 Pg. 366-9 (Jun 2006) ISSN: 0021-8820 [Print] England
• PMID: 16915823 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Oxazoles
• Salicylates
• transvalencin Z
• Salicylic Acid

Topics

• Anti-Bacterial Agents (chemistry, isolation & purification, pharmacology)
• Fermentation
• Humans
• Magnetic Resonance Spectroscopy
• Mass Spectrometry
• Nocardia (metabolism)
• Oxazoles (chemistry, isolation & purification, pharmacology)
• Salicylates (chemistry, isolation & purification, pharmacology)
• Salicylic Acid