Treatment of high-risk peripheral T-cell lymphomas other than anaplastic large-cell lymphoma with a dose-intensified CHOP regimen followed by high-dose chemotherapy. A single institution study.

Abstract

We investigated the efficacy of a dose-intensified double-CHOP regimen followed by high-dose chemotherapy with or without peripheral blood stem cell transplantation (PBSCT) in 11 patients with four types of peripheral T-cell lymphoma (PTCL). Three of the 4 patients with unspecified PTCL (PTCLu) achieved complete response (CR); 1 patient relapsed and 1 died of secondary leukemia after consolidation therapy. All angioimmunoblastic T-cell lymphoma (AILT) and subcutaneous panniculitis-like T-cell lymphoma (SPTCL) patients achieved CR; 5 of 6 have remained disease free for more than 3 years. The patient with hepatosplenic lymphoma did not achieve CR even after PBSCT and underwent allogenic bone marrow transplantation (allo-BMT). Thus, our regimen appears to be effective for high-risk AILT and SPTCL. However, allo-BMT should be considered for high-risk of PTCLu and hepatosplenic T-cell lymphoma.

• Authors: Tetsuo Yamazaki, Umihiko Sawada, Yoshimasa Kura, Takeyoshi Ito, Jin Takeuchi, Yoshihiro Hatta, Shingo Aikawa, Kazuhiro Takei, Hikaru Ishizuka, Minoru Saiki, Kumi Uenogawa
• Journal: Acta haematologica (Acta Haematol) Vol. 116 Issue 2 Pg. 90-5 ( 2006) ISSN: 0001-5792 [Print] Switzerland
• PMID: 16914902 (Publication Type: Journal Article)

Chemical References

• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisolone

Topics

• Adolescent
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Administration Schedule
• Female
• Humans
• Lymphoma, T-Cell (classification, drug therapy)
• Male
• Middle Aged
• Prednisolone (administration & dosage)
• Retrospective Studies
• Vincristine (administration & dosage)