Subcutaneous extralesional triamcinolone acetonide injection versus conservative management in the treatment of chalazion.

Abstract

OBJECTIVE:

To compare the efficacy of subcutaneous extralesional triamcinolone acetonide injection versus conservative treatment for chalazion.

DESIGN:

Randomised controlled trial.

SETTING:

Eye clinics of two regional hospitals in Hong Kong.

PATIENTS:

Patients over 18 years old presenting with primary chalazion were randomised into two groups. In group 1, 12 patients were treated with lid hygiene, warm compresses, and chloramphenicol 1% ointment 4 times a day. In group 2, 16 patients were treated with 0.3 mL triamcinolone acetonide (10 mg/mL) injection to the subcutaneous tissue extralesionally via the percutaneous route. Exclusion criteria were: acutely infected chalazion with preseptal cellulitis, recurrent chalazion, small chalazion (< or =2 mm), and prior treatment to chalazion.

MAIN OUTCOME MEASURES:

Size of chalazion, recurrence of chalazion, intra-ocular pressure, and complications from treatment, including skin pigmentary change or atrophy and pyogenic granuloma.

RESULTS:

There was a clinically and statistically significant difference between the success rates in group 1 (58.3%) and group 2 (93.8%). In group 1, the mean prior duration of chalazion before treatment was significantly shorter in success cases than in failed cases. One patient with multiple chalazia in group 2 developed hypopigmentary skin changes at one treatment site.

CONCLUSION:

Subcutaneous extralesional triamcinolone acetonide injection was more effective than conservative treatment for chalazion.

• Authors: C F Chung, J S M Lai, P S H Li
• Journal: Hong Kong medical journal = Xianggang yi xue za zhi (Hong Kong Med J) Vol. 12 Issue 4 Pg. 278-81 (Aug 2006) ISSN: 1024-2708 [Print] China
• PMID: 16912354 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Triamcinolone Acetonide

Topics

• Adult
• Chalazion (drug therapy)
• Female
• Humans
• Injections, Subcutaneous
• Male
• Middle Aged
• Triamcinolone Acetonide (administration & dosage)