Abstract | OBJECTIVE: DESIGN: Clinical trial. ANIMALS: 30 Holstein bull calves ranging from 5 to 6 months old and 75 to 200 kg (165 to 440 lb) with no history of Moraxella bovis infections, no history of M bovis vaccination, and negative results for M bovis on 3 consecutive ocular bacterial cultures. PROCEDURES: Both eyes of each calf were infected with 1 X 10(10) colony-forming units of piliated M bovis for 3 consecutive days prior to the trial. On day 0, ocular lesion scores were determined for each calf and the calves were weighed and assigned to a treatment (2.5 mg/kg [1.14 mg/lb] of body weight, SC) or control group according to a stratified random allocation based on weight and lesion score. Eyes were stained with fluorescein and photographed daily to record healing. Eyes were evaluated bacteriologically for M bovis on days 0 to 6 and at 3-day intervals thereafter. RESULTS: Median time to ulcer resolution in calves treated with tulathromycin was 9.1 days. More than 50% of control calves still had ulcers at the end of the trial (21 days). Moraxella sp was isolated less often from the eyes of treated calves than from the control calves. By day 10, the treated calves had lower ocular lesion scores than control calves. CONCLUSIONS AND CLINICAL RELEVANCE:
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Authors | V Michael Lane, Lisle W George, Dawn M Cleaver |
Journal | Journal of the American Veterinary Medical Association
(J Am Vet Med Assoc)
Vol. 229
Issue 4
Pg. 557-61
(Aug 15 2006)
ISSN: 0003-1488 [Print] United States |
PMID | 16910856
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Disaccharides
- Heterocyclic Compounds
- tulathromycin
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Topics |
- Animals
- Anti-Bacterial Agents
(therapeutic use)
- Cattle
- Cattle Diseases
(drug therapy, pathology)
- Disaccharides
(therapeutic use)
- Heterocyclic Compounds
(therapeutic use)
- Keratoconjunctivitis, Infectious
(drug therapy, pathology)
- Male
- Moraxella bovis
(drug effects)
- Moraxellaceae Infections
(drug therapy, pathology, veterinary)
- Time Factors
- Treatment Outcome
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