Mesencephalic projections to the thalamic centralis lateralis and medial prefrontal cortex: a WGA-HRP study.

Abstract

In order to provide anatomical information for a possible pathway involved in pain mechanisms, rats were injected with horseradish peroxidase wheat germ agglutinin (WGA-HRP) in the centralis lateralis nucleus of the thalamus (Cl) or in the medial prefrontal cortex (PFCx) from which originated retrogradely labelled cells in the dorsal raphe nucleus (DR), locus ceruleus (LC) and surrounding structures. The locations of the Cl and the PFCx injections were previously determined by the presence of evoked single neuronal responses to noxious stimulations. The present study gives evidence for ascending pathways which originated in DR and LC and project to the Cl and PFCx. LC and DR projections suggest a possible route to an ascending modulation pain system.

• Authors: M Condés Lara, M León Olea, M Sánchez Alvárez, I Omaña Zapata
• Journal: Brain research (Brain Res) Vol. 509 Issue 2 Pg. 321-4 (Feb 19 1990) ISSN: 0006-8993 [Print] Netherlands
• PMID: 1691039 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
• Wheat Germ Agglutinins
• Horseradish Peroxidase

Topics

• Animals
• Frontal Lobe (cytology)
• Horseradish Peroxidase
• Locus Coeruleus (cytology)
• Mesencephalon (cytology)
• Neural Pathways (anatomy & histology)
• Raphe Nuclei (cytology)
• Rats
• Rats, Inbred Strains
• Thalamic Nuclei (cytology)
• Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
• Wheat Germ Agglutinins