Abstract |
Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.
|
Authors | Mirjana Tosic, Jurg Ott, Sandra Barral, Pierre Bovet, Patricia Deppen, Fulvia Gheorghita, Marie-Louise Matthey, Josef Parnas, Martin Preisig, Michael Saraga, Alessandra Solida, Sally Timm, August G Wang, Thomas Werge, Michel Cuénod, Kim Quang Do |
Journal | American journal of human genetics
(Am J Hum Genet)
Vol. 79
Issue 3
Pg. 586-92
(Sep 2006)
ISSN: 0002-9297 [Print] United States |
PMID | 16909399
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- RNA, Messenger
- Glutamate-Cysteine Ligase
- Glutathione
|
Topics |
- Case-Control Studies
- Down-Regulation
- Fibroblasts
(enzymology, metabolism)
- Gene Frequency
- Genetic Predisposition to Disease
(genetics)
- Glutamate-Cysteine Ligase
(genetics)
- Glutathione
(metabolism)
- Humans
- Oxidative Stress
(genetics)
- Polymorphism, Single Nucleotide
- RNA, Messenger
(analysis)
- Schizophrenia
(enzymology, genetics)
|