Chronic inflammatory demyelinating polyneuropathy associated with idiopathic hemochromatosis.

Abstract

We describe a 50-year-old woman who developed chronic inflammatory demyelinating polyneuropathy (CIDP) one year after onset of hemochromatosis. Electrodiagnostic studies showed evidence of multifocal demyelination. Marked hypergammaglobulinemia with positive anti-nuclear and anti-DNA antibodies was found. Corticosteroid treatment resulted in a significant lessening of neurological symptoms. This is the first case of CIDP with hemochromatosis. The association may be coincidental, but the altered immune system by hemochromatosis was possibly related to the development of CIDP in this patient.

• Authors: Sonoko Misawa, Satoshi Kuwabara, Shinji Matsuda, Yumi Sakakibara, Yoshitsugu Ogawa, Jun Tashiro, Takamichi Hattori
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 45 Issue 14 Pg. 871-3 ( 2006) ISSN: 1349-7235 [Electronic] Japan
• PMID: 16908945 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Antibodies, Antinuclear

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Antibodies, Antinuclear (analysis)
• Electrodiagnosis
• Female
• Hemochromatosis (complications, diagnosis, immunology)
• Humans
• Hypergammaglobulinemia (diagnosis, immunology)
• Immune System (physiopathology)
• Middle Aged
• Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (diagnosis, drug therapy, etiology, immunology)