Abstract | OBJECTIVES: METHODS: Adult male SD rats were given high-dose L- thyroxin (0.2 mg/kg subcutaneously) once daily for 10 days to develop thyrotoxicosis. Subsets of the rats were treated with CPU 86017 or its four enantiomers (SR, SS, RS, and RR) once daily from day 6 to day 10. The alterations of redox, nitric oxide synthase, and endothelin-1 system in testes were examined by spectrophotometry and reverse transcriptase-polymerase chain reaction assay. RESULTS: CONCLUSIONS: High-dose L- thyroxin results in an overactive endothelin-1 system and oxidative stress in adult rat testis. CPU 86017 and its enantiomer SR suppressed the excessive ET-1 system by improving oxidative stress, and SR exhibited more potent efficacy than CPU 86017 and other enantiomers.
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Authors | XiaoYun Tang, MinYou Qi, DeZai Dai, Can Zhang |
Journal | Urology
(Urology)
Vol. 68
Issue 2
Pg. 455-61
(Aug 2006)
ISSN: 1527-9995 [Electronic] United States |
PMID | 16904483
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 4-chlorobenzyltetrahydroberberine
- Endothelin-1
- Berberine
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Topics |
- Animals
- Berberine
(analogs & derivatives, pharmacology)
- Endothelin-1
(physiology)
- Male
- Oxidative Stress
(drug effects)
- Rats
- Testis
(drug effects, metabolism)
- Thyrotoxicosis
(metabolism)
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