Abstract | OBJECTIVES: METHODS: We performed a MEDLINE search for PNET in urologic malignancies. Additionally, we report on 2 cases of renal and 1 case of bladder PNET. The data obtained by reviewing patients with renal PNET were analyzed using Kaplan-Meier analysis. RESULTS: Renal PNET is diagnosed in young adults (median age 24 years). In contrast, the incidence of bladder PNET seems to be dependent on a defective immune mechanism. Patients often present with pain (84%), palpable tumor (60%), and hematuria (38%). The radiologic findings are uncharacteristic; therefore, the diagnosis should be based on the histologic and immunohistochemistry findings. Renal and bladder PNET are both often diagnosed at an advanced stage and, therefore, the prognosis is poor, despite aggressive multimodal treatment (surgery, polychemotherapy, radiotherapy). We identified palpable tumor masses (log-rank test, P = 0.0027) and synaptophysin expression (log-rank test, P = 0.0422) as prognostic unfavorable markers for renal PNET. CONCLUSIONS:
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Authors | Jörg Ellinger, Patrick J Bastian, Stefan Hauser, Katharina Biermann, Stefan C Müller |
Journal | Urology
(Urology)
Vol. 68
Issue 2
Pg. 257-62
(Aug 2006)
ISSN: 1527-9995 [Electronic] United States |
PMID | 16904430
(Publication Type: Case Reports, Journal Article, Review)
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Topics |
- Adult
- Aged
- Diagnosis, Differential
- Female
- Humans
- Kidney Neoplasms
(diagnosis, therapy)
- Male
- Neuroectodermal Tumors, Primitive, Peripheral
(diagnosis, therapy)
- Urinary Bladder Neoplasms
(diagnosis, therapy)
- Urologic Neoplasms
(diagnosis, therapy)
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