Basement membrane biosynthesis as a target to tumor therapy.

Abstract

Tricyclodecan-9-yl-xanthate (D609) was identified as an agent that caused selective killing of tumor cells by an unknown mechanism of action. We report an inhibition by D609 of basement membrane collagen biosynthesis in the chick chorioallantoic membrane system in vitro. In the same system in vivo D609 inhibits angiogenesis. Also treatment of rats bearing Walker 256 carcinoma with D609 results in a dose-dependent antitumor effect. These results indicate that basement membrane synthesis may be a target for developing anti-angiogenic compounds with antitumor properties.

• Authors: M E Maragoudakis, E Missirlis, M Sarmonika, M Panoutsacopoulou, G Karakiulakis
• Journal: The Journal of pharmacology and experimental therapeutics (J Pharmacol Exp Ther) Vol. 252 Issue 2 Pg. 753-7 (Feb 1990) ISSN: 0022-3565 [Print] United States
• PMID: 1690295 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Bridged-Ring Compounds
• Norbornanes
• Thiocarbamates
• Thiones
• tricyclodecane-9-yl-xanthogenate
• Collagen

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Basement Membrane (drug effects, metabolism)
• Bridged-Ring Compounds (pharmacology)
• Carcinoma 256, Walker (pathology)
• Chickens
• Collagen (biosynthesis)
• Male
• Neoplasm Metastasis
• Neoplasms, Experimental (drug therapy)
• Neovascularization, Pathologic
• Norbornanes
• Rats
• Rats, Inbred Strains
• Thiocarbamates
• Thiones (pharmacology)
• Tumor Cells, Cultured (drug effects)