Scleromyxedema, a positive effect with thalidomide.

Abstract

Scleromyxedema is a rare dermatological disorder marked by widespread symmetric 2- to 3-mm, firm, waxy, closely spaced papules involving the hands, forearms, face, neck, upper trunk and thighs. The most common extracutaneous manifestation of scleromyxedema is a benign plasma cell dyscrasia. Treatment of scleromyxedema is limited by the lack of long-term results, toxicity and significant adverse side effects. We report a severe case of scleromyxedema who had marked improvement when treated with thalidomide.

• Authors: Sharon E Jacob, Sari Fien, Francisco A Kerdel
• Journal: Dermatology (Basel, Switzerland) (Dermatology) Vol. 213 Issue 2 Pg. 150-2 ( 2006) ISSN: 1018-8665 [Print] Switzerland
• PMID: 16902294 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2006 S. Karger AG, Basel.

Chemical References

• Angiogenesis Inhibitors
• Paraproteins
• Thalidomide

Topics

• Angiogenesis Inhibitors (therapeutic use)
• Female
• Follow-Up Studies
• Humans
• Middle Aged
• Paraproteins (drug effects, metabolism)
• Scleromyxedema (blood, drug therapy)
• Severity of Illness Index
• Thalidomide (therapeutic use)