Effect of 1-deamino 8-D-arginine vasopressin spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis.

Abstract

OBJECTIVE:

To determine any possible adverse effect of 1-deamino 8-D-arginine vasopressin (DDAVP) spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis.

METHODS:

Twenty-two children aged 6-16 enrolled in the study. Epithelial surface cells samples were taken from the nasal mucosa and mucociliary clearance time was calculated before and 1 and 6 months after administration of DDAVP spray.

RESULTS:

No qualitative changes in the epithelial surface cells and mucociliary clearance time were observed at 1 and 6 months after therapy.

CONCLUSION:

Based on the findings of the present study, DDAVP spray can be used for 6 months in children without apparent risk of damage to the epithelial surface cells and mucociliary clearance time.

• Authors: Ertap Akoğlu, Sadik Görür, Esin Atik, Semsettin Okuyucu, Ozlem Sangün
• Journal: International journal of pediatric otorhinolaryngology (Int J Pediatr Otorhinolaryngol) Vol. 70 Issue 11 Pg. 1919-22 (Nov 2006) ISSN: 0165-5876 [Print] Ireland
• PMID: 16901550 (Publication Type: Controlled Clinical Trial, Journal Article)

Chemical References

• Antidiuretic Agents
• Deamino Arginine Vasopressin

Topics

• Administration, Intranasal
• Adolescent
• Antidiuretic Agents (administration & dosage, adverse effects, therapeutic use)
• Child
• Cilia (drug effects, ultrastructure)
• Deamino Arginine Vasopressin (administration & dosage, adverse effects, therapeutic use)
• Female
• Humans
• Male
• Mucociliary Clearance (drug effects)
• Nasal Mucosa (drug effects, ultrastructure)
• Nocturnal Enuresis (drug therapy)