Abstract |
152 patients with thromboangiitis obliterans ( Buerger's disease) and pain from critical leg ischaemia were randomly allocated to receive iloprost, a chemically stable prostacyclin analogue, or low-dose aspirin, for 28 days in a double-blind trial. On review, 19 patients did not fulfil the stringent entry criteria. Of the other 133 patients, 98 also had leg ulcers. After 21-28 days, 58 (85%) of 68 iloprost-treated patients showed ulcer healing or relief of ischaemic pain, compared with 11 (17%) of 65 in the aspirin-treated group. 43 (63%) on iloprost treatment had complete relief of pain, compared with 18 (28%) on aspirin. Ulcers healed completely in 18 of 52 (35%) who received iloprost compared with 6 of 46 (13%) who received aspirin. 6 months after the start of treatment, the response rate was 45 of 51 (88%) patients treated with iloprost compared with 12 of 44 (21%) patients treated with aspirin.
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Authors | J N Fiessinger, M Schäfer |
Journal | Lancet (London, England)
(Lancet)
Vol. 335
Issue 8689
Pg. 555-7
(Mar 10 1990)
ISSN: 0140-6736 [Print] England |
PMID | 1689791
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Anti-Arrhythmia Agents
- Epoprostenol
- Iloprost
- Aspirin
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Topics |
- Adolescent
- Adult
- Amputation, Surgical
- Anti-Arrhythmia Agents
(administration & dosage, adverse effects, therapeutic use)
- Arm
(blood supply)
- Aspirin
(administration & dosage, adverse effects, therapeutic use)
- Double-Blind Method
- Drug Administration Schedule
- Drug Evaluation
- Epoprostenol
(administration & dosage, adverse effects, therapeutic use)
- Follow-Up Studies
- Humans
- Iloprost
- Ischemia
(drug therapy, etiology)
- Leg
(blood supply, surgery)
- Middle Aged
- Multicenter Studies as Topic
- Randomized Controlled Trials as Topic
- Thromboangiitis Obliterans
(complications, surgery)
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