Abstract | AIMS/HYPOTHESIS: MATERIALS AND METHODS: In the Study on Lifestyle Intervention and Impaired Glucose Tolerance Maastricht (SLIM), 97 men and women with IGT were randomised to a combined diet and exercise programme (47 intervention) or a control group (50 control subjects). At baseline and after 1 year the following assessments were made: an OGTT, an exercise test to determine maximal aerobic capacity, anthropometry, and analysis of the serum fatty acid profile of cholesteryl esters. RESULTS: The lifestyle programme was effective in reducing the intake of total and saturated fat, increasing physical activity, reducing obesity and improving insulin sensitivity and glucose tolerance. Regression analysis of the total population showed that an increase in the C20:4 n-6/C20:3 n-6 ratio (estimated Delta5-desaturase activity) and reductions in the C18:3 n-6/C18:2 n-6 ratio (estimated Delta6-desaturase activity) and the C16:1 n-7/C16:0 ratio (estimated Delta9-desaturase activity or stearoyl-CoA desaturase-1) were significantly associated with a decrease in homeostasis model assessment for insulin resistance. After adjustment for lifestyle changes (change in percentage body fat, aerobic capacity and saturated fat intake), these associations were partly reduced, but remained statistically significant. CONCLUSIONS/INTERPRETATION:
|
Authors | E Corpeleijn, E J M Feskens, E H J M Jansen, M Mensink, W H M Saris, T W A de Bruin, E E Blaak |
Journal | Diabetologia
(Diabetologia)
Vol. 49
Issue 10
Pg. 2392-401
(Oct 2006)
ISSN: 0012-186X [Print] Germany |
PMID | 16896932
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Blood Glucose
- Fatty Acids
- Insulin
- Fatty Acid Desaturases
|
Topics |
- Blood Glucose
(metabolism)
- Body Mass Index
- Body Size
- Body Weight
- Cohort Studies
- Diet
- Energy Metabolism
- Exercise
- Fatty Acid Desaturases
(blood)
- Fatty Acids
(blood)
- Female
- Follow-Up Studies
- Glucose Intolerance
(blood, psychology)
- Glucose Tolerance Test
- Humans
- Insulin
(blood)
- Life Style
- Male
- Middle Aged
- Netherlands
|