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[Results of chemotherapy in patients with disseminated testicular tumors].

Abstract
Results of treatment of 44 patients with disseminated non-seminomatous testicular tumors versus advancement are discussed in the paper. In cases of minimal and moderate advancement (group 1), induction chemotherapy included three cycles of VAB-6 regimen (vinblastine, actinomycin D, bleomycetin, cyclophosphamide plus 120 mg/m2 platidiam) whereas cases of advanced tumor (group 2) received six such cycles; two of them used 150 mg/m2 platidiam dropwise in a 3% sodium chloride solution. Complete regression was observed in 22 of 24 (96.1%) patients of group 1 and in seven out of 20 (35%) cases of group 2; it was registered in 100, 81.8 and 38% of patients with minimal, moderately- and far-advanced disease, respectively. Patients were followed for 4-23 months (average 14.5 months). Eight cases relapsed. At the time of this writing, 38 out of 44 (86.3%) patients are alive, and 23 out of 29 (79.3%) continue in complete remission. Toxicity was moderate. Application of 3% NaCl prevented nephrotoxicity of high-dose (150 mg/m2) platidiam.
AuthorsT A Abdyldaev, S A Tiuliandin, S V Batov
JournalVoprosy onkologii (Vopr Onkol) Vol. 36 Issue 1 Pg. 85-9 ( 1990) ISSN: 0507-3758 [Print] Russia (Federation)
Vernacular TitleRezul'taty khimioterapii bol'nykh s disseminirovannymi opukholiami iaichka.
PMID1689527 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Bleomycin
  • Chlorambucil
  • Dactinomycin
  • Vinblastine
  • Doxorubicin
  • Cyclophosphamide
  • Cisplatin
Topics
  • Adolescent
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Bleomycin (administration & dosage)
  • Chlorambucil (administration & dosage)
  • Cisplatin (administration & dosage)
  • Cyclophosphamide (administration & dosage)
  • Dactinomycin (administration & dosage)
  • Doxorubicin (administration & dosage)
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Germ Cell and Embryonal (drug therapy, mortality, pathology)
  • Testicular Neoplasms (drug therapy, mortality, pathology)
  • Testis (pathology)
  • Time Factors
  • Vinblastine (administration & dosage)

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