Amide proton transfer imaging of human brain tumors at 3T.

Abstract

Amide proton transfer (APT) imaging is a technique in which the nuclear magnetization of water-exchangeable amide protons of endogenous mobile proteins and peptides in tissue is saturated, resulting in a signal intensity decrease of the free water. In this work, the first human APT data were acquired from 10 patients with brain tumors on a 3T whole-body clinical scanner and compared with T1- (T1w) and T2-weighted (T2w), fluid-attenuated inversion recovery (FLAIR), and diffusion images (fractional anisotropy (FA) and apparent diffusion coefficient (ADC)). The APT-weighted images provided good contrast between tumor and edema. The effect of APT was enhanced by an approximate 4% change in the water signal intensity in tumor regions compared to edema and normal-appearing white matter (NAWM). These preliminary data from patients with brain tumors show that the APT is a unique contrast that can provide complementary information to standard clinical MRI measures.

• Authors: Craig K Jones, Michael J Schlosser, Peter C M van Zijl, Martin G Pomper, Xavier Golay, Jinyuan Zhou
• Journal: Magnetic resonance in medicine (Magn Reson Med) Vol. 56 Issue 3 Pg. 585-92 (Sep 2006) ISSN: 0740-3194 [Print] United States
• PMID: 16892186 (Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright (c) 2006 Wiley-Liss, Inc.

Chemical References

• Amides
• Protons

Topics

• Algorithms
• Amides
• Body Water (metabolism)
• Brain Neoplasms (diagnosis, metabolism)
• Humans
• Image Enhancement (methods)
• Image Interpretation, Computer-Assisted (methods)
• Magnetic Resonance Imaging (methods)
• Protons
• Reproducibility of Results
• Sensitivity and Specificity