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[Effects of dexamethasone on acute lung injury in rats induced by lipopolysacharide].

AbstractOBJECTIVE:
To study the difference between the preventive and therapeutic effects of dexamethasone on acute lung injury models induced by lipopolysacharide (LPS) in different phases.
METHODS:
Forty adult male Wistar rats were randomly divided into four groups: (1)control group to receive intraperitoneal NS injection (2 mL/kg). (2)LPS group to receive intraperitoneal LPS injection (5 mg/kg). (3)one-hour group to receive intraperitoneal dexamethasone injection (2 mg/kg) one hour after LPS injection. (4)three-hour group to receive intraperitoneal dexamethasone injection (2 mg/kg) three hours after LPS injection. Then histopathology, arterial blood gases, lung permeability, wet-to-dry weight ratio and immunohistochemistry AQP1 were performed 24 hours later.
RESULTS:
Dexamethasone could improve biological indexes. Lung permeability, wet-to-dry weight ratio and immunohistochemistry AQP1 were (5.73+/-1.37), (4.92+/-0.23), (19.92+/-6.47) in LPS group, (2.4+/-0.51), (4.89+/-0.21), (33.47+/-9.41) in one-hour group and (2.15+/-0.63), (4.57+/-0.14), (40.69+/-9.18) in three-hour group, respectively. Dates in three-hour group were prior to those of one-hour group, and there was slight but no significant difference between the two groups.
CONCLUSION:
Dexamethasone can improve lung permeability and reduce lung edema. There is no need to be treated with glucocorticoids in advance.
AuthorsQin Lin, Guang-fa Wang, Xiu-ying Tang, Shui-lan Zou
JournalBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences (Beijing Da Xue Xue Bao Yi Xue Ban) Vol. 38 Issue 4 Pg. 393-6 (Aug 18 2006) ISSN: 1671-167X [Print] China
PMID16892145 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Aqp1 protein, rat
  • Lipopolysaccharides
  • Aquaporin 1
  • Dexamethasone
Topics
  • Acute Disease
  • Animals
  • Anti-Inflammatory Agents (administration & dosage, therapeutic use)
  • Aquaporin 1 (analysis)
  • Dexamethasone (administration & dosage, therapeutic use)
  • Immunohistochemistry
  • Injections, Intraperitoneal
  • Lipopolysaccharides (administration & dosage, toxicity)
  • Lung (drug effects, metabolism, pathology)
  • Lung Diseases (chemically induced, drug therapy)
  • Male
  • Random Allocation
  • Rats
  • Rats, Wistar

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