Abstract | OBJECTIVE: METHODS: Forty adult male Wistar rats were randomly divided into four groups: (1)control group to receive intraperitoneal NS injection (2 mL/kg). (2)LPS group to receive intraperitoneal LPS injection (5 mg/kg). (3)one-hour group to receive intraperitoneal dexamethasone injection (2 mg/kg) one hour after LPS injection. (4)three-hour group to receive intraperitoneal dexamethasone injection (2 mg/kg) three hours after LPS injection. Then histopathology, arterial blood gases, lung permeability, wet-to-dry weight ratio and immunohistochemistry AQP1 were performed 24 hours later. RESULTS:
Dexamethasone could improve biological indexes. Lung permeability, wet-to-dry weight ratio and immunohistochemistry AQP1 were (5.73+/-1.37), (4.92+/-0.23), (19.92+/-6.47) in LPS group, (2.4+/-0.51), (4.89+/-0.21), (33.47+/-9.41) in one-hour group and (2.15+/-0.63), (4.57+/-0.14), (40.69+/-9.18) in three-hour group, respectively. Dates in three-hour group were prior to those of one-hour group, and there was slight but no significant difference between the two groups. CONCLUSION:
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Authors | Qin Lin, Guang-fa Wang, Xiu-ying Tang, Shui-lan Zou |
Journal | Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
(Beijing Da Xue Xue Bao Yi Xue Ban)
Vol. 38
Issue 4
Pg. 393-6
(Aug 18 2006)
ISSN: 1671-167X [Print] China |
PMID | 16892145
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Aqp1 protein, rat
- Lipopolysaccharides
- Aquaporin 1
- Dexamethasone
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Topics |
- Acute Disease
- Animals
- Anti-Inflammatory Agents
(administration & dosage, therapeutic use)
- Aquaporin 1
(analysis)
- Dexamethasone
(administration & dosage, therapeutic use)
- Immunohistochemistry
- Injections, Intraperitoneal
- Lipopolysaccharides
(administration & dosage, toxicity)
- Lung
(drug effects, metabolism, pathology)
- Lung Diseases
(chemically induced, drug therapy)
- Male
- Random Allocation
- Rats
- Rats, Wistar
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