Abstract |
A multicenter, randomized, investigator-blind controlled trial was conducted to compare the safety and efficacy of a single, whole-body application of 5% permethrin cream with that of 1% lindane lotion for the treatment of scabies in 467 patients. At 14 +/- 3 days after treatment, the mean active lesion count decreased from pretreatment levels of 85 (range, 4 to 600) in both treatment groups to 14 (range, 0 to 133) in the permethrin group and to 15 lesions (range, 0 to 500) in the lindane group. At 28 +/- 7 days after treatment, complete resolution had occurred in 181 (91%) of 199 patients treated with permethrin and in 176 (86%) of 205 patients given lindane. Pruritus due to scabies persisted at 28 +/- 7 days in 14% of the permethrin group and in 25% of the lindane group. The most frequent adverse effects were new or increased pruritus and mild, transient burning or stinging; the latter was slightly more frequent following permethrin treatment and appeared to be related to severity of infestation. Because of a lower potential for neurologic toxicity, permethrin may be preferable to lindane for the treatment of scabies particularly in children.
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Authors | M W Schultz, M Gomez, R C Hansen, J Mills, A Menter, H Rodgers, F N Judson, G Mertz, H H Handsfield |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 126
Issue 2
Pg. 167-70
(Feb 1990)
ISSN: 0003-987X [Print] United States |
PMID | 1689135
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Insecticides
- Pyrethrins
- Permethrin
- Hexachlorocyclohexane
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Hexachlorocyclohexane
(administration & dosage, therapeutic use)
- Humans
- Infant
- Insecticides
(administration & dosage, therapeutic use)
- Male
- Middle Aged
- Multicenter Studies as Topic
- Permethrin
- Pyrethrins
(administration & dosage, therapeutic use)
- Randomized Controlled Trials as Topic
- Scabies
(drug therapy)
- Single-Blind Method
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