Abstract |
Although the gastrointestinal (GI) tract is the most common site of primary extranodal lymphomas, the lineage of these tumors has been controversial. The authors used paraffin-reactive antibodies detecting markers of B-, T-, histiocytic, and epithelial cells to study 34 non-Hodgkin's lymphomas of the GI tract for which unequivocal frozen-section immunophenotypine was available as a control to determine whether these antibodies are reliable in the study of these tumors. Frozen-section studies revealed 31 tumors of B-cell origin and three T-cell tumors. Paraffin-reactive antibodies confirmed B-cell lineage in 28 of the 31 cases, with equivocal results in the remaining three. Only one of the T-cell lymphomas was identified in paraffin studies. Our results indicate that paraffin-reactive antibodies can reliably identify most B-cell lymphomas in the GI tract but may be unreliable in the detection of lymphomas of T-cell origin.
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Authors | B C Wolf, A W Martin, H J Ree, P M Banks, S Smith, R S Neiman |
Journal | American journal of clinical pathology
(Am J Clin Pathol)
Vol. 93
Issue 2
Pg. 233-9
(Feb 1990)
ISSN: 0002-9173 [Print] England |
PMID | 1689097
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antigens, Neoplasm
- Paraffin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antigens, Neoplasm
(analysis)
- B-Lymphocytes
(pathology)
- Evaluation Studies as Topic
- Female
- Frozen Sections
- Gastrointestinal Neoplasms
(metabolism, pathology)
- Humans
- Immunoenzyme Techniques
- Lymphoma, Non-Hodgkin
(metabolism, pathology)
- Male
- Middle Aged
- Paraffin
- Phenotype
- Pilot Projects
- Retrospective Studies
- Staining and Labeling
- T-Lymphocytes
(pathology)
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