[Use of yasmin in the treatment of women with polycystic ovary syndrome].

Abstract

AIM OF STUDY:

To prove the clinical efficiency over hyperandrogenism in women with PCOS after the application of the combined oral contraceptive Yasmin containing 30 mcg ethynilestradiol and 2 mg drospirenone.

METHODS:

Prospective open study over 15 women taking Yasmin for six months. At the beginning and at the end of the study the following values have been checked--the Ferriman-Gallwey /F-G/ index, BMI, the waist/hip ratio (WHR), some hormonal and biochemical indexes--testosterone, SHBG, immune reactive insulin (IRI), glucose, as well as the values of free androgenic index (FAI) and insulin resistance (HOMA).

RESULTS:

All fifteen women completed 6 months of therapy. The drug has been accepted very well. At the end of the study there was a significant improvement of hirsutism, expressed in the decrease of F-G index, accompanied by an increase of testosterone and SHBG values. The carbohydrate parameters haven't changed significantly.

CONCLUSION:

Yasmin is an effective drug in the treatment of hyperandrogenism in women with PCOS with few side effects and no significant influence over insulin resistance.

• Authors: B Pekhlivanov, M Mitkov, Kh Ivancheva, I Amaliev
• Journal: Akusherstvo i ginekologiia (Akush Ginekol (Sofiia)) Vol. 45 Issue 3 Pg. 25-9 ( 2006) ISSN: 0324-0959 [Print] Bulgaria
• PMID: 16889184 (Publication Type: English Abstract, Journal Article)

Chemical References

• Androstenes
• Mineralocorticoid Receptor Antagonists
• drospirenone

Topics

• Adult
• Androstenes (administration & dosage, therapeutic use)
• Body Mass Index
• Drug Administration Schedule
• Female
• Hirsutism (complications, drug therapy, metabolism)
• Humans
• Mineralocorticoid Receptor Antagonists (administration & dosage, therapeutic use)
• Polycystic Ovary Syndrome (complications, drug therapy, metabolism)
• Prospective Studies
• Treatment Outcome
• Waist-Hip Ratio