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New developments in the chemistry and biology of the bioactive constituents of Tanshen.

Abstract
Tanshen, the rhizome of Salvia miltiorrhiza Bunge, has been used in Chinese traditional medicine (TCM) for multiple therapeutic remedies. The major constituents of Tanshen include water-soluble phenolic acids and lipophilic tanshinones. Phenolic acids possess antioxidant and anticoagulant activities, whereas tanshinones show antibacterial, antioxidant, and antineoplastic activities. This review will focus on recent developments concerning the chemical constituents of Tanshen and their biological activities. These chemical and biological studies continue to increase our understanding about a scientific basis for the traditional clinical use of Tanshen and can also contribute to the development of new drug candidates. Recently, in the author's laboratory, a new compound, neo-tanshinlactone, was discovered to have potent selective antibreast cancer activity. This compound might serve as a lead for developing promising antibreast cancer clinical trials candidates.
AuthorsXihong Wang, Susan L Morris-Natschke, Kuo-Hsiung Lee
JournalMedicinal research reviews (Med Res Rev) Vol. 27 Issue 1 Pg. 133-48 (Jan 2007) ISSN: 0198-6325 [Print] United States
PMID16888751 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
CopyrightCopyright 2006 Wiley Periodicals, Inc.
Chemical References
  • Abietanes
  • Anti-Infective Agents
  • Anticoagulants
  • Antihypertensive Agents
  • Antineoplastic Agents, Phytogenic
  • Antioxidants
  • Drugs, Chinese Herbal
  • Hydroxybenzoates
  • Phenanthrenes
  • tanshinone
  • phenolic acid
Topics
  • Abietanes
  • Animals
  • Anti-Infective Agents (chemistry, pharmacology)
  • Anticoagulants (chemistry, pharmacology)
  • Antihypertensive Agents (chemistry, pharmacology)
  • Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
  • Antioxidants (chemistry, pharmacology)
  • Drugs, Chinese Herbal (chemistry, pharmacology)
  • Humans
  • Hydroxybenzoates (chemistry, pharmacology)
  • Phenanthrenes (chemistry, pharmacology)
  • Salvia miltiorrhiza (chemistry)

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