Abstract | INTRODUCTION: PATIENTS AND METHODS: The nails of 80 consecutive renal transplant recipients receiving sirolimus have been evaluated in a systematic dermatological study in 2003. The patients were mainly men (60%) with a mean age of 48 years. The mean duration of the graft was 6 years and of sirolimus treatment 18 months. Mycophenolate mofetil and steroids were combined with sirolimus in 86% of patients. RESULTS: Fifty-seven patients (74%) complained for nail alterations. The most frequent anomalies (88%) were matrix alterations including slow growth, onychomalacia, onychorrexis, and leukonychia. Nail bed alterations ( onycholysis), vascular phenomenon ( erythema, splinter hemorrhages), and periungual anomalies (mainly pyogenic granulomas) were observed in 42, 42 and 19% of cases respectively. One observation of type 1 photo-onycholysis was described. DISCUSSION:
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Authors | E Mahé, E Morelon, S Lechaton, H Kreis, Y De Prost, C Bodemer |
Journal | Annales de dermatologie et de venereologie
(Ann Dermatol Venereol)
2006 Jun-Jul
Vol. 133
Issue 6-7
Pg. 531-5
ISSN: 0151-9638 [Print] France |
Vernacular Title | Onychopathie associée au sirolimus chez les transplantés rénaux. |
PMID | 16885839
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Sirolimus
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Topics |
- Female
- Humans
- Immunosuppressive Agents
(administration & dosage, adverse effects)
- Kidney Transplantation
- Male
- Middle Aged
- Nail Diseases
(chemically induced)
- Sirolimus
(administration & dosage, adverse effects)
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