MMP-2 assessment as an indicator of wound healing: A feasibility study.

Abstract

OBJECTIVE:

Evaluate the feasibility of assessment of fibroblast matrix metalloproteinase-2 (MMP-2) expression as an indicator of wound healing in wounds that change from chronically inert to actively healing.

METHODS:

Phase II feasibility study of 4 patients with nonhealing wounds (duration, > or = 3 months; surface area, > or = 1 cm). Wounds were treated with a dressing impregated with oak bark extract (DerMax) and evaluated weekly; biopsies were performed every 2 weeks until wound healing.

RESULTS:

Therapy-induced wound healing and immunohistochemical measurements of MMP-2 expression paralleled the clinical characteristics of wound healing.

CONCLUSION:

MMP-2 expression offers a reliable indicator for clinical wound healing induced by DerMax treatment.

• Authors: Refaat B Karim, Beatriz L R Brito, Richard P Dutrieux, Fernanda P Lassance, J Joris Hage
• Journal: Advances in skin & wound care (Adv Skin Wound Care) 2006 Jul-Aug Vol. 19 Issue 6 Pg. 324-7 ISSN: 1527-7941 [Print] United States
• PMID: 16885646 (Publication Type: Case Reports, Clinical Trial, Phase II, Journal Article)

Chemical References

• Biomarkers
• PHI-5 formulation
• Matrix Metalloproteinase 2
• Zinc
• Rubidium

Topics

• Adult
• Aged
• Bandages
• Biomarkers (analysis)
• Biopsy
• Drug Monitoring (methods)
• Feasibility Studies
• Female
• Humans
• Immunohistochemistry (methods, standards)
• Leg Ulcer (pathology, therapy)
• Male
• Matrix Metalloproteinase 2 (analysis)
• Middle Aged
• Phytotherapy
• Plant Bark
• Rubidium (administration & dosage, chemistry)
• Single-Blind Method
• Wound Healing
• Zinc (administration & dosage, chemistry)