Uterine tumor resembling ovarian sex cord tumors in a patient using tamoxifen: report of a case and review of literature.

Abstract

Increasing number of uterine malignancies have been reported in breast cancer patients using tamoxifen. Most of these are endometrial adenocarcinomas. However, only a few cases of endometrial stromal sarcomas have been reported to be linked with tamoxifen usage. A 58-year-old postmenopausal women who had been using tamoxifen for 4 years after a surgery for breast cancer is presented with chronic pelvic pain. Preoperative investigations were indicative of a uterine myoma so that a standard total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. Postoperative histologic diagnosis was a uterine tumor resembling ovarian sex cord tumors, which is an exceedingly rare entity itself. The present case is the first designated diagnosis of this rare tumor, with a possible association of tamoxifen usage.

• Authors: O Oztekin, F Soylu, S Yigit, E Sarica
• Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (Int J Gynecol Cancer) 2006 Jul-Aug Vol. 16 Issue 4 Pg. 1694-7 ISSN: 1048-891X [Print] England
• PMID: 16884388 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Tamoxifen

Topics

• Antineoplastic Agents, Hormonal (adverse effects)
• Breast Neoplasms (drug therapy)
• Diagnosis, Differential
• Female
• Humans
• Hysterectomy
• Middle Aged
• Ovariectomy
• Postmenopause
• Sex Cord-Gonadal Stromal Tumors (chemically induced, diagnosis, surgery)
• Tamoxifen (adverse effects)
• Uterine Neoplasms (chemically induced, diagnosis, surgery)