HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Comparative evaluation of the neuroprotective activity of phenibut and piracetam under experimental cerebral ischemia conditions in rats].

Abstract
The neuroprotective properties of phenibut and piracetam were studied in rats with cerebral ischemia caused by bilateral irreversible simultaneous occlusion of carotid arteries and gravitational overload in craniocaudal vector. In addition, the effects of both drugs on microcirculation in brain cortex under ischemic injury conditions were studied. Phenibut and (to a lower extent) piracetam reduced a neuralgic deficiency, amnesia, and the degree of cerebral circulation drop, and improved the spontaneous movement and research activity deteriorated by brain ischemia.
AuthorsI N Tiurenkov, M N Bagmetov, V V Epishina, L E Borodkina, A V Voronkov
JournalEksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2006 May-Jun Vol. 69 Issue 3 Pg. 19-22 ISSN: 0869-2092 [Print] Russia (Federation)
PMID16878492 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anticonvulsants
  • Neuroprotective Agents
  • gamma-Aminobutyric Acid
  • 4-amino-3-phenylbutyric acid
  • Piracetam
Topics
  • Animals
  • Anticonvulsants (administration & dosage)
  • Brain Ischemia (drug therapy)
  • Cerebral Cortex (blood supply)
  • Cerebrovascular Circulation (drug effects)
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Male
  • Neuroprotective Agents (administration & dosage)
  • Piracetam
  • Rats
  • Rats, Wistar
  • gamma-Aminobutyric Acid (administration & dosage, analogs & derivatives)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: