Lack of carriers of citrullinaemia and DUMPS in Indian Holstein cattle.

Abstract

The present study investigated the occurrence of 2 autosomal recessive genetic diseases, bovine citrullinaemia and deficiency of uridine monophosphate synthase (DUMPS), in Indian Holstein cattle. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed on a group of 642 animals, mainly HF and HF crossbred cattle, to identify carriers of these diseases. None of the animals were carriers of citrullinaemia or DUMPS. It is possible that with the mounting selection pressure, the international gene pool may diminish, and consequently the risk of dissemination of inherited defects will increase. It is therefore recommended to screen breeding bulls for their breed-specific genetic diseases before they are inducted in artificial insemination programmes, to minimize the risk.

• Authors: Rajesh K Patel, Krishna M Singh, Kalpesh J Soni, Jenabhai B Chauhan, Krothapalli R S Sambasiva Rao
• Journal: Journal of applied genetics (J Appl Genet) Vol. 47 Issue 3 Pg. 239-42 ( 2006) ISSN: 1234-1983 [Print] England
• PMID: 16877802 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Multienzyme Complexes
• uridine 5'-monophosphate synthase
• Orotate Phosphoribosyltransferase
• Orotidine-5'-Phosphate Decarboxylase

Topics

• Animals
• Breeding (methods)
• Cattle
• Cattle Diseases (epidemiology, genetics)
• Citrullinemia (epidemiology, genetics, veterinary)
• Genetic Carrier Screening
• India (epidemiology)
• Multienzyme Complexes (deficiency, genetics)
• Orotate Phosphoribosyltransferase (deficiency, genetics)
• Orotidine-5'-Phosphate Decarboxylase (deficiency, genetics)
• Polymorphism, Restriction Fragment Length