HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Porphyran induces apoptosis related signal pathway in AGS gastric cancer cell lines.

Abstract
Porphyrans, the sulfated polysaccharides, are the main components of Porphyra. The potential apoptotic activities of porphyran were evaluated using AGS human gastric cancer cells. Porphyran did not affect the growth of normal cells, but did induce cancer cell death in a dose-dependent manner. The addition of 0.1% porphyran also reduced DNA synthesis after 24 h of exposure, suggesting that porphyran inhibits cancer cell growth by both decreasing cell proliferation and inducing apoptosis. AGS cells treated with porphyran displayed a marked increase in poly(ADP-ribose) polymerase (PARP) cleavage, as well as caspase-3 activation. The ability of porphyran to promote apoptosis may contribute to its usefulness as an agent capable of significantly inhibiting cell growth in AGS human gastric cancer cells. Insulin-like growth factor-I receptor (IGF-IR) phosphorylation was decreased in porphyran-treated AGS cells compared to control cells, which correlated with Akt activation. Thus, porphyran appears to negatively regulate IGF-IR phosphorylation by causing a decrease in the expression levels in AGS gastric cancer cells, and then inducing caspase-3 activation.
AuthorsMi-Jin Kwon, Taek-Jeong Nam
JournalLife sciences (Life Sci) Vol. 79 Issue 20 Pg. 1956-62 (Oct 12 2006) ISSN: 0024-3205 [Print] Netherlands
PMID16876203 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • porphyran
  • Sepharose
  • Poly(ADP-ribose) Polymerases
  • Receptor, IGF Type 1
  • Proto-Oncogene Proteins c-akt
  • CASP3 protein, human
  • Caspase 3
  • Caspases
Topics
  • Apoptosis
  • Caspase 3
  • Caspases (metabolism)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • DNA Replication (drug effects)
  • Enzyme Activation (drug effects)
  • Humans
  • Phosphorylation (drug effects)
  • Poly(ADP-ribose) Polymerases (metabolism)
  • Proto-Oncogene Proteins c-akt (metabolism)
  • Receptor, IGF Type 1 (analysis, metabolism)
  • Sepharose (analogs & derivatives, pharmacology)
  • Signal Transduction (drug effects)
  • Stomach Neoplasms (enzymology, genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: