Abstract | BACKGROUND: The purpose of this study is to investigate the efficacy of an intensive chemotherapy induction regimen followed by myeloablative chemotherapy and autologous hematopoietic stem cell rescue (AHSCR) in children with newly diagnosed ependymoma. PATIENTS AND METHODS: RESULTS: The estimated 5-year event free survival (EFS) and overall survival (OS) from diagnosis were 12% (+/-6%) and 38% (+/-10%), respectively. The toxic mortality amongst this group of 29 patients was 10.3%. Younger age (less than 18 months at diagnosis) was the only statistically significant prognostic factor. The estimated 5-year OS rate for the five patients with metastatic disease at presentation was 80% (+/-18%). Overall, radiation-free survival at 5 years from diagnosis was 8% (+/-5%). CONCLUSIONS: The use of an intensive induction chemotherapy regimen including myeloablative chemotherapy followed by AHSCR in newly diagnosed young children with ependymoma is not superior to other previously reported chemotherapeutic strategies.
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Authors | Stergios Zacharoulis, Adam Levy, Susan N Chi, Sharon Gardner, Marc Rosenblum, Douglas C Miller, Ira Dunkel, Blanca Diez, Richard Sposto, Lingyun Ji, Shahab Asgharzadeh, Juliette Hukin, Jean Belasco, Ronald Dubowy, Stewart Kellie, Amanda Termuhlen, Jonathan Finlay |
Journal | Pediatric blood & cancer
(Pediatr Blood Cancer)
Vol. 49
Issue 1
Pg. 34-40
(Jul 2007)
ISSN: 1545-5009 [Print] United States |
PMID | 16874765
(Publication Type: Journal Article)
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Chemical References |
- Vincristine
- Etoposide
- Cyclophosphamide
- Thiotepa
- Carboplatin
- Cisplatin
- Methotrexate
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Brain Neoplasms
(diagnosis, therapy)
- Carboplatin
(administration & dosage)
- Child
- Child, Preschool
- Cisplatin
(administration & dosage)
- Combined Modality Therapy
- Cyclophosphamide
(administration & dosage)
- Disease-Free Survival
- Ependymoma
(diagnosis, therapy)
- Etoposide
(administration & dosage)
- Female
- Follow-Up Studies
- Hematopoietic Stem Cell Transplantation
- Humans
- Infant
- Male
- Methotrexate
(administration & dosage)
- Neoplasm Recurrence, Local
(therapy)
- Thiotepa
(administration & dosage)
- Transplantation, Autologous
- Treatment Outcome
- Vincristine
(administration & dosage)
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