N-hexacosanol reverses diabetic induced muscarinic hypercontractility of ileum in the rat.

Abstract

Diabetic neuropathy, a major complication of diabetes mellitus, is associated with development of gastrointestinal motility dysfunction and autonomic neuropathy. N-hexacosanol has neurotrophic effects and exhibits a wide variety of biological actions. In this study, we investigated the effects of cyclohexenonic long-chain fatty alcohol (N-hexacosanol) on streptozotocin-diabetic hypercontractility in the rat ileum longitudinal muscles. Treatment with N-hexacosanol did not alter the diabetic status of the animals, i.e., body weight, serum glucose, and serum insulin levels, but significantly restored the thickness of intestine wall and ameliorated diabetes-induced hypercontractility of the rat ileum in a dose-dependent manner. Furthermore, N-hexacosanol reversed the diabetes-induced upregulation of intestinal muscarinic M(2) and M(3) receptors mRNAs in the streptozotocin-diabetic rats. These results indicate that N-hexacosanol has therapeutic effects on hypercontractility in the diabetic ileum by ameliorating overexpression of muscarinic M(2) and M(3) receptors mRNAs.

• Authors: Chiko Shinbori, Motoaki Saito, Yukako Kinoshita, Itaru Satoh, Tomoharu Kono, Takuya Hanada, Eiji Nanba, Kaori Adachi, Hiroto Suzuki, Masashi Yamada, Keisuke Satoh
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 545 Issue 2-3 Pg. 177-84 (Sep 18 2006) ISSN: 0014-2999 [Print] Netherlands
• PMID: 16872599 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fatty Alcohols
• Receptor, Muscarinic M2
• Receptor, Muscarinic M3
• Streptozocin
• 1-hexacosanol
• Calcium

Topics

• Animals
• Calcium (metabolism)
• Diabetes Mellitus, Experimental (physiopathology)
• Diabetic Neuropathies (drug therapy)
• Fatty Alcohols (pharmacology, therapeutic use)
• Ileum (drug effects, physiopathology)
• Male
• Muscle Contraction (drug effects)
• Rats
• Rats, Sprague-Dawley
• Receptor, Muscarinic M2 (drug effects, genetics)
• Receptor, Muscarinic M3 (drug effects, genetics)
• Streptozocin