Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury.

Abstract

Previous studies have demonstrated that polydatin, a crystal component extracted from the root stem of the perennial herbage Polygonum Cuspidatum Sieb.et Zucc, exerts a neuroprotective effect on cerebral injury induced by ischemia/reperfusion. To investigate the possible mechanism of this action, we determined the effects of polydatin on the expression of cell adhesion molecules (CAMs) after ischemia-induced cerebral injury. Rats were treated with polydatin (i.v.) immediately after the operation of middle cerebral artery occlusion (MCAO) for 1 h. It was found that polydatin improved neurological deficits and reduced the volume of brain infarction. In addition, polydatin decreased the levels of CAMs relative to the control (MCAO alone); these included intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, L-selectin and Integrins. These results suggest that polydatin exerts protective effects likely via inhibition of the expression of various CAMs; polydatin may be a potential agent for treatment of brain injury associated with stroke.

• Authors: Yufang Cheng, Han-Ting Zhang, Lisha Sun, Shenglan Guo, Shi Ouyang, Yanjun Zhang, Jiangping Xu
• Journal: Brain research (Brain Res) Vol. 1110 Issue 1 Pg. 193-200 (Sep 19 2006) ISSN: 0006-8993 [Print] Netherlands
• PMID: 16870162 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glucosides
• Neural Cell Adhesion Molecules
• Neuroprotective Agents
• Stilbenes
• Vascular Cell Adhesion Molecule-1
• Intercellular Adhesion Molecule-1
• polydatin

Topics

• Analysis of Variance
• Animals
• Brain (drug effects)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Gene Expression (drug effects)
• Glucosides (therapeutic use)
• Immunohistochemistry (methods)
• Intercellular Adhesion Molecule-1 (genetics, metabolism)
• Male
• Neural Cell Adhesion Molecules (classification, physiology)
• Neurologic Examination (methods)
• Neuroprotective Agents (therapeutic use)
• Oligonucleotide Array Sequence Analysis (methods)
• Rats
• Rats, Sprague-Dawley
• Reperfusion Injury (pathology, prevention & control)
• Stilbenes (therapeutic use)
• Vascular Cell Adhesion Molecule-1 (genetics, metabolism)